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Can the Niners return in Week 5?

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Game requirements: The 49ers (2-2) at the Cardinals (4-0) at the State Farm Stadium in Glendale, Arizona at 1:25 p.m. (PT). TV: Fox TV (Ch2), announcers: Kevin Kogler (play-by-play), Mark Sanchez (color commentary), Laura O’Keefe (sideline reporting).

ODDS: Cardinals -5.5. top bottom: 50

Series: 49ers 32-27 ahead. Last meeting: The 49ers won 20-12. December 26, 2020 at State Farm Stadium.

The 49ers enter Sunday’s game after losing two games in which players suffered injuries in their initial offense and defense.

The Cardinals enter the game with the NFL’s only unbeaten record and MVP’s top candidate in the youth season.

But by 5 p.m., San Francisco can only find one game behind Arizona in the NFC West, one leg on top of the tiebreaker and the rest of the game at home between the two teams in less than a month. There is such a life in the NFL, especially now in the early 17th game season.

The Niners nearly doubled Seattle’s total yardage in their loss on Sunday afternoon, but the second game, which had two turnovers and no takeaways, was spellbound. It’s only been four games, but the 49ers ‘minus-5 turnover margin is the third-worst in the NFL, while the Cardinals’ plus-5 margin is the third-best.

One player who can help make such a difference is Treylance, the No. 3 overall pick in this year’s draft who will start his first NFL on Sunday.

He relieved an injured Jimmy Garopolo in the second half last week and when he didn’t appear to be throwing the ball too fast (9 of 18 for 157 yards), he provided a new dynamic (41 rushing yards) and Garopolo Gained more points while protecting the ball

It remains to be seen whether a week of preparation can help him measure up against early MVP front-runner Killer Murray. Murray is completing an impressive 76% of his effort at an average of 9.5 yards per effort – and his speed threat puts the defense on high alert.

Share your thoughts on the game with our reporters Cam Inman and Jerry McDonald, columnist Dieter Kurtinbach and other analysts.

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